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The objective of my project is to go beyond inventories of redox modified proteins by monitoring the proteome-wide dynamics of disulphide-dithiol status in the context of a diurnal metabolic cycle in the green alga Chlamydomonas reinhardtii. The findings will be important for modelling diurnal metabolic flux, which is useful for developing biotechnological strategies, whether synthetic biology or pharmacological, for manipulating metabolism for production of biofuels and bioproducts, where Chlamydomonas is a key reference organism.

Ojeda, V., Jiménez-López, J., Romero-Campero, F.J., Cejudo, F.J., Pérez-Ruiz, J.M. A chloroplast redox relay adapts plastid metabolism to light and affects cytosolic protein quality control.  Plant Physiology. 2021 DOI: 10.1093/plphys/kiab246

Cejudo, F.J., Ojeda, V., Delgado-Requerey, V., González, M., Pérez-Ruiz, J.M. Chloroplast redox regulatory mechanisms in plant adaptation to light and darkness. Frontiers in Plant Science. 2019 DOI: 10.3389/fpls.2019.00380

Ojeda, V., Pérez-Ruiz, J.M., Cejudo, F.J. 2-Cys peroxiredoxins participate in the oxidation of chloroplast enzymes in the dark. Molecular Plant. 2018; 11(11):1377-1388. DOI: 10.1016/j.molp.2018.09.005

Ojeda, V., Pérez-Ruiz, J.M., Cejudo, F.J. The NADPH-dependent thioredoxin reductase C-2-Cys peroxiredoxin redox system modulates the activity of thioredoxin x in Arabidopsis chloroplasts. Plant and Cell Physiology. 2018; 59 (10): 2155-2164. DOI: 10.1093/pcp/pcy134

Pérez-Ruiz, J.M, Naranjo, B., Ojeda, V., Guinea, M., Cejudo, F.J. NTRC-dependent redox balance of 2-Cys peroxiredoxins is needed for optimal function of the photosynthetic apparatus. Proceedings of the National Academy of Sciences of the USA. 2017; 114 (45): 12069-12074. DOI: 10.1073/pnas.1706003114

Ojeda, V., Nájera, V.A., González, M., Pérez-Ruiz, J.M., Cejudo, F.J. Photosynthetic activity of cotyledons is critical during post-germinative growth and seedling establishment. Plant Signaling & Behavior. 2017; 12 (9): e-1347244. DOI: 10.1080/15592324.2017

Ojeda, V., Pérez-Ruiz, J.M., González, M., Nájera, V.A., Sahrawy, M., Serrato, AJ., Geigenberger, P., Cejudo, F.J. NADPH thioredoxin reductase C and thioredoxins act concertedly in seedling development. Plant Physiology. 2017; 174 (3): 1436-1448. DOI: 10.1104/pp.17.00481

Bernal-Bayard, P., Ojeda, V., Hervás, M., Cejudo, F.J., Navarro, J.A., Velázquez-Campoy, A., Pérez-Ruiz, J.M. Molecular recognition in the interaction of chloroplast 2-Cys peroxiredoxin with NADPH-thioredoxin reductase C (NTRC) and thioredoxin x. FEBS Letters. 2014; 588 (23): 4342-4347. DOI: 10.1016/j.febslet.2014.09.044